APOB and obesity due to melanocortin 4 receptor deficiency: Aryal et al. (2016) found that the expression of Cd36 increased in Angptl4−/− macrophages. Apo a and Apo b are mainly studied in obesity and cardiovascular diseases, studies suggest that Apoa1, Apo b, and Apo b/Apoa1 ratio have been regarded as the predictors of microvascular and macrovascular complications of diabetes (Moosaie et al., 2020). These genes are concentrated in PPAR signaling pathway, which is thought to be involved in the regulation of glucose and lipid metabolism, endothelial function and inflammation (Wang, Dougherty & Danner, 2016).