The mRNA levels of the 13 overlapping genes were verified by qRT-PCR in DKD and control mice kidney tissues, meanwhile, the results indicated that the mRNA levels of Aacs, Cpe, Cd36, Slc22a7, Slc1a4, Lpl, Cyp7b1, Akr1c14, Apoh were down-regulated, while Abcc4 and Gsta2 were up-regulated, these changes were statistically significant (p < 0.05). The gene discussed is AACS; the disease is diabetic kidney disease.