Carboxy peptidase E (Cpe), an enzyme that converts the pro-insulin to insulin, which suggest that Cpe may be related to the occurrence of T2DM (Sabiha et al., 2021), rescuing proinsulinmia caused by reduced CPE may be a new approach to treat early diabetes (Jo, Lockridge & Alejandro, 2019). This evidence concerns the gene CPE and diabetes mellitus.