CDK4 and central nervous system cancer: In vitro, cRGD-P/ARV-DOX micelles triggered G2/M-phase cell cycle arrest and promoted tumor cells apoptosis in glioma cells via suppressing the activation of STAT3 and AKT, downregulating p-FOXO1/FOXO1, cyclin D1 and CDK4, activating caspase cascade, downregulating Bcl-2 and upregulating Bax, resulting in obvious tumor suppression.