It is known that its active metabolite accumulates in kidneys, liver and digestive tract24; thus, its most frequent adverse drug effects are kidney injury and hepatic enzymes elevation44, which can ultimately increase COVID-19 severity in patients with pre-existing complications45 Remdesivir use could be hazardous for patients with ALT or AST levels that are 5 times higher than the upper limit of normal, patients with the estimated glomerular filtration rate (eGFR) <30 mL/min, as well as pregnant or lactating women24. The gene discussed is GPT; the disease is COVID-19.