ICAM1 and Lyme disease: Local inflammation at the site of a tick bite is a hallmark of early Lyme disease (erythema migrans),[29] and is characterized by upregulation of cytokines and chemokines associated with recruitment and activation of immune cells.[30] Here we found that Bb alone can induce activation of the endothelium resulting in increased expression of adhesion molecules (e.g., ICAM‐1) and leukocyte adhesion.