p53 also exerts essential regulatory effects on the cardiovascular system during physiological processes such as embryonic heart development and adult heart homeostasis119, 120 as well as during the development of CVDs including atherosclerosis, myocardial IRI, heart failure, diabetic‐induced or pressure‐overload maladaptive remodeling, and chemotherapy‐induced cardiotoxicity.121, 122, 123, 124. The gene discussed is TP53; the disease is heart failure.