Gain‐of‐function mutations, on the other hand, enable p53 to acquire new transcriptional targets,117 such as p63, p73, NF‐Y, Sp1, ETS1/2, NF‐κB, ATM, and SMADs, modifying the metabolism, cell cycle, and apoptosis of tumor cells and promoting genomic instability, cell proliferation, metastasis, and therapy resistance.118. Here, TP53 is linked to neoplasm.