HAO1 and neoplasm: Glucose oxidase (GOx), a prominent endogenous oxidoreductase for cancer starvation therapy, can deplete intracellular glucose and O2 to produce H2O2 and gluconic acid.[20] By consuming glucose, the GOx can effectively inhibit the production of intracellular adenosine triphosphate (ATP).[21] As we all know, the expression of HSP was highly positively correlated with ATP content.[22] Therefore, inhibiting the production of intratumoral ATP by GOx‐mediated starvation therapy can be a promising method to overcome HSPs‐induced tumor thermoresistance.