Nevertheless, the up‐regulated protective heat shock proteins (HSPs) within cancer cells and PD‐L1 expressed on the surface of cancer cells induced by heat stress often cause suboptimal PTT effect.[17] To shrinking the thermoresistance of cancer cell, a number of small molecule HSPs inhibitors (GA, 17‐AAG etc.)have been exploited.[18] Regrettably, these HSPs inhibitors can only inhibit the activity of the already generated HSPs after heat stimulus rather than before therapy,[19] resulting in delayed therapeutic effect. Here, CD274 is linked to cancer.