Subsequently, high CRT and HMGB1 expressions favor in vivo DC maturation and impel activation and expansion of effector T (CD8+) including cytotoxic T lymphocytes (CTLs, IFNγ+CD8+) in tumor‐draining lymph nodes (TDLNs) (Figures S7a–f and S8, Supporting Information), accompanied with cytokines secreted by matured DCs (IL‐6 and TNF‐α) and activated CD8+ T cells (IL‐12 and INF‐γ) in the serum, which are up‐regulated (Figure S7g–j, Supporting Information). The gene discussed is HMGB1; the disease is neoplasm.