KLRK1 and neoplasm: All these appealing actions contributed to the boosted ICD and ICB with repressed primary and distant tumor progression and reduced metastasis in vitro and in vivo The success of ICD and ICB immunotherapy indirectly verified the successful ITM, vascular homeostasis re‐shaping, and systematic immune response activation, thereby ensuring massive replication of NKG2D CARs‐engineered CAR‐T cells for exerting the persistent CAR‐T immunotherapy against solid MDA‐MB‐231 tumor in NSG mice in vivo.