Systematic results validated that such intraparticle double‐scattering‐decoded sonogenetics in ICG/PDE5i@FRMON reactivated the exhausted immune responses, elevated the immune potency, remodeled ITM, propelled vascular normalization, opened IB, and induced an influx of endogenous tumor‐specific CD8(+) T cells. This evidence concerns the gene CD8A and neoplasm.