ZBTB40 and inflammatory bowel disease: While more modest, we also observed that the HITS for IBD ORFs ETS2 and ZBTB40 shared a significant GO annotation (immune system process) (S3A, S3B, S4A and S5A Tables). Expressing the ORFs of ETS2 or ZBTB40 in THP-1 cells resulted in up- or down-regulation of a common set of genes (S3 Fig) primarily involved in the recruitment and extravasation of inflammatory cells [20–24].