However, some of the pathways previously described as dysregulated in breast cancer that our algorithm found significant were not identified by the tree based method, such as ‘Human Papilloma virus infection’, ‘Epstein-bar virus infection’, ‘PI3K/Akt/mTOR signalling pathway’, ‘Calcium Signaling pathway’ and ‘Mineral absorption’. The gene discussed is AKT1; the disease is breast carcinoma.