TP53 and central nervous system cancer: KEGG pathway analyses also showed the pathways enrichment of high-risk group in cell cycle, such as chemokine signaling pathway, cytokine–cytokine receptor asssociations, glioma, hedgehog and p53 signaling pathways, pathways in cancer, T-cell receptor signaling pathway, primary immunodeficiency and VEGF signaling pathway (Figure 6B).