Nevertheless, the very different levels of infection (and ensuing differences in tissue injury) may contribute to the aforementioned differences in down-regulated genes, with the comparable levels of virus infection seen in the K18-hACE2 mouse groups (Fig 2A) contributing to the higher level of congruence (i.e. 17/20 significant GSEAs) (Fig 2B, purple crosses). The gene discussed is KRT18; the disease is infection.