The pathways for downregulated mRNAs in chronic low-temperature acclimation group were Oxytocin signaling pathway and Calcium signaling pathway (Fig 2C), whereas Thyroid cancer, Small cell lung cancer, and Regulation of lipolysis in adipocytes were the significant pathways for downregulated mRNAs in acute short cold stress group (Fig 2D). The gene discussed is OXT; the disease is thyroid gland carcinoma.