In the RISK study, TCF7L2 SNP rs7901695 did not modulate the effect of dietary interventions on the change of acute insulin secretion, insulin sensitivity, and deposition index (a measure of the beta cell's ability to compensate for changes in insulin resistance) during 24 weeks of intervention in participants who were at risk of T2DM [48]. This evidence concerns the gene INS and type 2 diabetes mellitus.