In Diabetes Prevention Program (DDP) and Diabetes Prevention Program Outcomes Study (DPPOS), in response to lifestyle modification, no difference in insulin concentration, insulin-secretion, or insulin-sensitivity indices was observed by rs7903146 and rs12255372 over a one-year follow-up among participants who were at risk of progression to T2DM [33, 34]. The gene discussed is INS; the disease is diabetes mellitus.