Since then, a growing number of FARS2 deleterious variants have been identified in three different disorders: COXPD14 with early-onset encephalopathy with or without epilepsy, COXPD14 with juvenile-onset epilepsy, and spastic paraplegia type 77 (SPG77, MIM: 617046) [9]. The gene discussed is FARS2; the disease is Encephalopathy.