Repressor element 1-silencing transcription factor (REST), also called neuron-restrictive silencing factor, regulates genes mediating cell death, stress resistance, and AD pathology; is induced in the aging human brain and almost absent in the nucleus of vulnerable cortical and hippocampal neurons of AD brains; and correlates with cognitive preservation during aging and with longevity [27]. The gene discussed is REST; the disease is Alzheimer disease.