Correlations at baseline of this biomarker with MMSE (r = –0.278, p = 0.004) and ADAS-cog+(r = 0.266, p = 0.006) in the RCT and with MMSE in the NDEV Study are also indicating a negative relationship between NDEV total tau and cognition in our AD population. This evidence concerns the gene MAPT and Alzheimer disease.