Recent investigations in AD demonstrated that circulating NDEV contain pathological molecules such as Aβ142 (Aβ42), total and phosphorylated tau, and synaptic proteins [10–12]; which may contribute to the spread of AD pathology [9, 13, 14], and can serve as effective disease biomarkers [7–9, 15, 16]. This evidence concerns the gene MAPT and Alzheimer disease.