MAPT and Alzheimer disease: In the population of AD patients, and after controlling for the influence of covariates, NDEV levels of total tau, NRGN, and REST correlated negatively with MMSE (Total tau: r = –0.267, p < 0.01; NRGN: r = –0.262, p < 0.01; REST: r = –0.194, p < 0.05) and ADCS-ADL scores (Total tau: r = –0.226, p < 0.05; NRGN: r = –0.257, p < 0.01; REST: r = –0.269, p < 0.01), and showed positive correlations with ADAS-cog+scores (Total tau: r = 0.237, p < 0.05; NRGN: r = 0.293, p < 0.01; REST: r = 0.225, p < 0.05).