In addition, tumor-derived T cells that were treated with GITRL demonstrated increased frequencies of both IFN-γ+ and TNF-α+ cells and enhanced secretion of pro-inflammatory proteases and chemokines (eg, CCL3, CCL4, CXCL9), potentially driving immune cells attraction and activation in the TME in vivo.46 Here, CXCL9 is linked to neoplasm.