Compared with PBMC and adjacent tissues, GITR expression was increased on CD8+ TIL from CRC (9.7% ± 1.1% vs 0.6% ± 0.1% and 3.6% ± 0.6%, respectively) and CRLM (8.4% ± 1.5% vs 1.8% ± 0.4% and 1.6% ± 0.3%, respectively) (Figure 5C and D). This evidence concerns the gene TNFRSF18 and colorectal carcinoma.