Regarding CA19-9-negative IPMN patients (n = 286), 27.3% of patients had elevated serum CA125 levels (cut-off value = 13.4 U/ml), and 8.0% of patients had elevated serum CEA levels (cut-off value = 5.3 μg/L). This evidence concerns the gene MUC16 and pancreatic intraductal papillary-mucinous neoplasm.