SPP1 and cancer: More detailed pan-cancer research focusing on the T cells and myeloid cells in the TIME revealed the existence of granzyme K (GZMK)+ Tem, interferon-stimulated genes (ISG)+ T cells, killer cell immunoglobulin like receptor (KIR)+ NKT cells, transcription factor 7 (TCF7)+ CD8+ T cells, ficolin 1 (FCN1)+ conventional DC (cDC)2, secreted phosphoprotein 1 (SPP1)+ TAMs, and folate receptor beta (FOLR2)+ TAMs in the tumour microenvironment [105, 106].