TGFB1 and breast carcinoma: Furthermore, scRNA-seq of breast cancer indicated that the angiogenesis factors plasminogen activator, urokinase receptor (PLAUR) and IL-8 were expressed in TAMs in addition to M2-type genes, such as CD163, membrane spanning 4-domains A6A (MS4A6A), and transforming growth factor beta-1 (TGF-β1) [113].