Researchers discovered communications between CAFs and gastric cancer cells via integrin receptor interactions with collagen, fibronectin, thrombospondin 1 (THBS1) ligands, and leucine rich repeat containing G protein-coupled receptor 4 (LGR4)- R-spondin 3 (RSPO3), which regulate stemness [110]. This evidence concerns the gene RSPO3 and gastric cancer.