CXCL12 and cancer: For instance, TAMs were found to have decreased CXCL12- C-X-C motif chemokine receptor (CXCR)3 and CXCL12-CXCR4 interactions and enhanced CD86-CTLA-4 interactions between cytotoxic T cells and Tregs in nasopharyngeal carcinoma, resulting in a TIME that aggravates cancer progression [138].