Among these 14 promising proteins are Igs, which are a hallmark of MS disease and have been implemented in most recent MS diagnostic criteria in the form of oligoclonal Ig gamma (IgG) bands.16 Also, the kappa subtype of Ig has been studied as a potential biomarker for MS diagnosis and alternative for OCB.19 Two of five implicated Igs have been previously associated with POMS, namely Ig heavy constant gamma 15 and Ig heavy constant gamma 2. This evidence concerns the gene CUBN and myeloid sarcoma.