Three of these five neuron-related proteins have been reported previously with increased abundance in MS, of which CPE5,6 and NEGR5 only in POMS, and BCAN both in POMS5 and adult-onset multiple sclerosis (AOMS).30 Strikingly, SEMA7A was observed in lower concentrations in adults with clinically isolated syndromes (CIS) subsequently ascertained as having clinically definite MS versus CIS patients who remained monophasic during multiple years of follow-up,31 while in our study, we found an increased abundance in POMS versus mADS. This evidence concerns the gene SEMA7A and in situ carcinoma.