MAPT and Alzheimer disease: We included a total of 612 participants consisting of non-demented and demented individuals with biomarker evidence of AD including elevated amyloid-PET accumulation (Aβ + , ADNI: n = 275; BioFINDER-1: n = 102) and CN controls without elevated amyloid-PET and tau-PET (Aβ-/Tau-, ADNI: n = 199; BioFINDER-1: n = 36, see Table 1).