In contrast, nmBc1-2 expressed a different set of chemokines and chemokine receptors than mBc1-4 including CXCL3, CXCL5, CCR3, CCR7, CCR9, CXCR1, CXCR4, and CXCR5. Since the CXCL13–CXCR5 axis is pivotal in recruiting Bc [37], non-malignant Bc might have been attracted from the periphery to the tumor by malignant Bc during lymphoma progression. Here, CXCR4 is linked to lymphoma.