Endothelial cells and astrocytes will also play a significant role after stroke; Jun Xiang and colleagues evaluated how astrocyte-endothelial cell interaction could influence stoke pathogenesis in an oxygen and glucose deprivation-reoxygenation (OGD-R) model and reported that astrocyte-derived apoE activated the PI3k/eNOS pathway in endothelial cells as protection mechanism [723]. Here, APOE is linked to stroke disorder.