This phenotype has several transcriptomic similarities with other neurodegenerative phenotypes previously described by Krasemann and colleagues [673], such as upregulation of Axl, Lpl, and importantly, apoE. Thus, investigating the role of apoE isoforms in this microglial phenotype could help better understand the role of apoE and microglia in PD onset, dementia development, and α-syn clearance. The gene discussed is APOE; the disease is Parkinson disease.