Conversely, in a rat model of subarachnoid hemorrhage, an intraperitoneal dose of an apoE-mimic peptide and LRP1 ligand (COG1410) revealed that microglial LRP1 activation alleviates white matter injury and improves neurological functioning by shifting microglia towards an M2 phenotype through the activation of the Shc/PI3k/Akt signaling pathway [318]. The gene discussed is APOE; the disease is subarachnoid hemorrhage.