Similarly, a meta-analysis carried out by the Swedish Heart and Lung foundation with combined information including the APOE alleles, sex, age of onset of ischemic stroke, stroke severity, and outcome, established a link between the APOE4 allele expression and younger age of stroke onset, so as a link between APOE4 and favorable stoke outcomes, whereas APOE2 allele male carriers were directly related with poor stroke outcomes. This evidence concerns the gene APOE and ischemic stroke.