Since the abovementioned positive IMbrave150 results, in which the combined therapy of the immune checkpoint inhibition atezolizumab and the VEGF antibody bevacizumab showed significantly improved survival outcome, the number of trials on immune checkpoint inhibition in combination with other biological therapies for unresectable HCC has tremendously increased [5, 6, 43]. The gene discussed is VEGFA; the disease is hepatocellular carcinoma.