Telomerase-mediated TMM in neuroblastoma can be determined by detecting the respective genomic alterations, i.e., amplification of MYCN (MNA) or rearrangements of TERT (TERT RA) [10], or by examining TERT expression levels [6, 9, 10] or telomerase activity [6, 12]. The gene discussed is MYCN; the disease is neuroblastoma.