Moreover, plasmonic AgPd PB nanozyme exhibited both CAT (through Eley–Rideal mechanism) and POD-mimic activities (through Fenton-like mechanism), which were demonstrated to catalyze TME-enriched H2O2 to into O2 to relieve tumor hypoxia or into toxic •OH to induce apoptosis in vitro and in vivo. The gene discussed is CAT; the disease is neoplasm.