For example, interferon signaling, ErbB2-ErbB3 signaling, PPARα/RXRα activation, fatty acid synthesis, and NF-κB activation are shown in Fig. 3B. Importantly, we also identified an immune response pathway that is mediated by HMGB1 and associated with inflammation, cell differentiation and tumor cell migration. Here, HMGB1 is linked to neoplasm.