Several aberrant pathways, including Janus kinase/signal transducer and activator of transcription (JAK/STAT), phosphotylinosital 3 kinase/protein kinase B-mammalian target of rapamycin (PI3K/AKT-mTOR), mitogen-activated protein kinase (MAPK), transforming growth factor-β (TGF-β) and wingless (Wnt) pathways, has been identified in previous reports, suggesting comprehensive abnormalities and huge heterogeneity of HCC [7–9]. Here, MTOR is linked to hepatocellular carcinoma.