MDS/MPN-RS-T is the most distinct entity from a molecular perspective, characterized in most cases by mutations in SF3B1 in combination with an MPN driver mutation in JAK2. Mutations in several other genes may be present, with ASXL1 and SETBP1 considered as adverse prognostic markers [36]. The gene discussed is SETBP1; the disease is myeloproliferative neoplasm.