HOTAIRM1 is an oncogenic lncRNA, and in recent years, it has been proved to regulate the proliferation and invasiveness of many malignant tumors and affect the prognosis of tumors [40–42].However, some studies have found that HOTAIRM1 played an anti-cancer role in some tumors [43–45] and its specific biological function in lung adenocarcinoma is still unclear. This evidence concerns the gene HOTAIRM1 and cancer.