SPON2 and lung adenocarcinoma: Second, SPON2 expression was more downregulated after inhibiting lung adenocarcinoma exosome release than we expected, suggesting that other regulatory mechanisms derived from lung adenocarcinoma exosomes may exist.Third, due to limitation of time and funding, the role of SPON2 and corresponding mechanism have only been confirmed in cell experiments, and further verification in animal experiments is lacking.