SPON2 and cancer: HOTAIRM1 can regulate neuronal differentiation and promote osteogenesis in physiological state, and inhibit T-cell depletion in late sepsis, so as to reduce lung injury and improve the survival rate.HOTAIRM1 has been proved to promote the progression of lung adenocarcinoma [17, 18], and its positive correlation with SPON2 expression attracts our interest, which means that it may also have other cancer promoting pathways.However, the exact mechanism is unclear.