In recent years, SPON2 has been proved to promote cancer progression in many malignant tumors, such as by regulating Notch signaling pathway or activates integrin β1/Pyk2 axis to promote tumor migration and growth and is associated with lymph node metastasis [31, 35–37]. The gene discussed is PTK2B; the disease is metastatic malignant neoplasm in the lymph nodes.