Elevated circulating aldosterone levels, due either to salt-depletion or aldosterone infusion in patients with mild hypertension, increased the excretion of mannan-binding lectin associated serine protease 2 (MASP-2 (protein)/MASP2 (gene)) in urinary extracellular vesicles (EVs)14, which are nano-sized vesicles released from all nephron segments, containing proteins from their parental cell15. The gene discussed is MASP2; the disease is hypertensive disorder.