MAPT and Alzheimer disease: The top-ranked DMP, which was characterized by increasing DNA methylation with increased tau pathology (cg07061298: P = 8.06E–18, effect size = 0.32%, Fig. 3a) is annotated to HOXA3; of note, previous studies have strongly implicated differential DNA methylation across the HOXA region as being associated with AD pathology13,46,47, and we found that 17 (5%) of the 334 meta-analysis DMPs are annotated to this genomic region (Supplementary Fig. S16).