SPI1 and Alzheimer disease: Interestingly, several of the identified DMPs are annotated to genes that been also been implicated in GWAS analyses of AD pathology, including cg06784824 (P = 1.71E–11, effect size = 0.21%, Fig. 3c) annotated to SPI1, a gene hypothesized to regulate AD-associated genes in primary human microglia7,48.