Although we attempted to control for potential heterogeneity in the proportion of different cell-types in our analysis of bulk cortex DNA methylation by using novel reference panels generated on NeuN+ (neuron-enriched), SOX10+ (oligodendrocyte-enriched), and NeuN–/SOX10– (microglia- and astrocyte-enriched) nuclei populations, our EWAS approach could not identify AD-associated differences occurring within specific cell populations. Here, SOX10 is linked to Alzheimer disease.