To address the functional consequences of FRAT1 cooperating with FRAT2 on tumour metastasis, we inoculated MKN45 cells transduced with Lv-vector, Lv-FRAT1, Lv-shRNA, Lv-FRAT2 shRNA2, or Lv-FRAT1 + FRAT2 shRNA2 into BALB/c-nu/nu mice (Fig. 5F and Supplementary Fig. 6D). The gene discussed is FRAT2; the disease is neoplasm.