Also for OspC B. spielmanii, severe COVID-19 patients demonstrated significantly higher specific IgM levels than the group of participants seronegative to SARS-CoV-2 (Fig. 2, all p-values are listed in Supplementary Table S3, numbers of patients testing positively for each antigen-specific IgM are listed in Supplementary Table S4). The gene discussed is CD40LG; the disease is COVID-19.