While our peptide-based IMQ-TCI approach takes advantage of the direct access to skin-resident APCs and activation in a TLR7-dependent way, further activation signals have been necessary so far to improve cancer or virus-specific immunity, i.e. by UV exposure15, immune checkpoint blockade18, or CD40 ligation19 This already suggests additional APC activation may optimize TCI-induced immune responses. Here, TLR7 is linked to cancer.