Other than these top hits, there are few antifungal compounds like Itraconazole (used for treatment of pulmonary and extrapulmonary blastomycosis), Isavuconazonium and Amphotericin B. Amphotericin B is known to counteract the antiviral activity of IFITM3 by preventing an increase in the membrane order13,37. Here, IFITM3 is linked to blastomycosis.