CPSF6 and attention deficit-hyperactivity disorder: Several of these miRNAs may regulate a number of central genes (those with high intramodular connectivity) from module M1, such as CPSF6 encoding a subunit of a cleavage factor required for the RNA cleavage and polyadenylation processing, which was previously related to externalizing behaviors including ADHD [46], and RICTOR, which plays an essential role during the neurodevelopment and has been associated with hyperactivity and reduced anxiety-like behavior in conditional knock-out mice in the dorsal neural progenitor cells [47].