To determine the functional significance of enhanced adipocyte MHCII expression, we co-cultured isolated adipocytes with bead-isolated CD4 + T cells obtained from PB of the same subjects with obesity (n = 3) using Copaxone as the antigen, which has been shown to enhance CD4 + Th1 cell differentiation in multiple sclerosis14. The gene discussed is CD4; the disease is obesity due to melanocortin 4 receptor deficiency.