For example, rs2168101, a polymorphism within an SE element located in the first intron of LMO1, influences neuroblastoma susceptibility by changing GATA transcription factor binding and regulating LMO1 expression.92 rs539846, which resides in the SE (located in intron 3) of BMF, influences chronic lymphocytic leukaemia susceptibility through differential RELA binding and modulation of BMF expression.93 Despite the important roles of genetic variants in SEs in complex diseases, so far, the role of risk variants located in SEs in SCZ pathogenesis is unclear. The gene discussed is RELA; the disease is B-cell chronic lymphocytic leukemia.