A recent meta-analysis confirmed that p16 and p16/Ki-67 immunocytochemistry has higher specificity for cervical intraepithelial neoplasia of grade 2 or worse (CIN2+) or cervical intraepithelial neoplasia of grade 3 or worse (CIN3+) than the hrHPV DNA testing [16]. This evidence concerns the gene MKI67 and cervical intraepithelial neoplasia.