Moreover, these three DNA methylation regulatory gene expression patterns correlated with three distinct tumor immune response phenotypes, namely, immune-excluded for pattern A, immune-desert for pattern B, immune-inflamed phenotype for pattern C. Glioma patients belonging to the DNA methylation regulatory gene expression pattern C were significantly enriched with immune cell types such an activated DCs, CD8+ T cells, co-stimulatory T cells, activated mast cells, and activated NK cells. Here, CD8A is linked to central nervous system cancer.