Moreover, consistent with the clinicopathological features, glioma samples in gene cluster B showed higher proportions of resting CD4 memory T cells, resting NK cells, and resting mast cells in the TME and were significant positively correlated with the activation of EMT and pan-F-TBRS, thereby demonstrating the immune-desert phenotype (Figure 4C, 4D). Here, CD4 is linked to glioma.