TP53 and central nervous system cancer: Patterns A and C demonstrated an immune activation phenotype with enrichment of immune pathways such as the chemokine signaling pathway, cytokine-cytokine receptor interaction, and arachidonic acid metabolism; glioma in pattern B were enriched in stromal activation-related pathways, such as p53 signaling pathway, RNA degradation, cell cycle, and DNA replication (Figure 2E, 2F; Supplementary Table 3).