CNV analysis in the glioma samples demonstrated high frequency of amplifications in MBD3, TDG, UHRF1, DNMT1, and MECP2, and copy number deletions in UHRF2, SMUG1, ZBTB38, MBD4, MBD2, TET2, MBD1, and ZBTB4 (Figure 1C). Here, MBD3 is linked to central nervous system cancer.