In our group’s previous experiments, we occasionally found that the combination of PTX and QUE inhibits resistance to PTX in NSCLC by inhibiting Akt and ERK phosphorylation and MMP depolarization (Wang et al., 2021), based on the fact that QUE could be a chemosensitizer and interferes with the hydrolytic activity of ATPase to alleviate resistance to PTX by noncompetitive binding and blocking efflux. This evidence concerns the gene AKT1 and non-small cell lung carcinoma.