During UPEC‐UTI AQP2 mRNA abundance determined by qRT‐PCR was significantly reduced in NH4Cl‐A and neutrophil‐depleted versus normal‐infected or uninfected isotype‐control mice, respectively (AQP2: Normal vs. Normal average (N vs. Navg) = 1.0 ± 0.2; NH4Cl‐A = 0.41 ± 0.09* and N vs. Navg =1.0 ± 0.1 Neutr. Here, AQP2 is linked to bacterial urinary tract infection.