Increased adherence to EDII yielded an increase of 16.73 mg/l in leptin level (β= 16.73, 95% CI= 1.56, 39.3, P= 0.04) and 0.55 in leptin resistance (β=0.55, 95% CI=0.00, 1.30, P= 0.06) in model 2, which was adjusted for, economic status, education level, age of starting obesity, weight loss history. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.