APOE and Alzheimer disease: A more recent study from Leonenko et al. [18] further evaluated how best to model the APOE4 effect in the context of PRS and found that the best prediction accuracy to predict AD cases from controls (AUC = 74.1%) came from a combination of a PRS excluding the APOE region with the addition of the weighted sum of two directly genotyped APOE ε2 and ε4 alleles (rs429358, rs7412, PRSnoAPOE+APOEε2+ε4) and a threshold pT < 0.1.