STMN1 mRNA expression is higher in ACC samples in the E-TABM-311 cohort as compared to NC, adrenocorticotropic hormone-independent macronodular adrenal hyperplasia (AIMAH), and ACA (p < 0.001) (Fig. 7B). Here, POMC is linked to Cushing syndrome due to macronodular adrenal hyperplasia.