SLC5A2 and type 2 diabetes mellitus: Our results demonstrating that a multivariable risk-strategy is more efficient to guide SGLT2 initiation than a strategy based on a single risk marker (i.e., HbA1c or albuminuria) are consistent with previous studies showing the micro- and macrovascular complications in patients with type 2 diabetes are determined by multiple risk markers, and support the measurement of biomarker panels to adequately capture individual risk and guide individualized treatment decisions [36, 37].