Finally, we demonstrated a large variation in the predicted 5-year benefit of the SGLT2 inhibitor canagliflozin for the composite kidney and heart failure or CV death outcomes and that treating patients with type 2 diabetes with the SGLT2 inhibitor canagliflozin according to a multivariable risk prediction model is more effective than a treatment strategy based on HbA1c or UACR alone. This evidence concerns the gene SLC5A2 and heart failure.