CXCL5 and gastric cancer: In our study, we only focused on the chemokines CXCL5 derived from TAMs and illuminated its critical role in 5-FU-resistnace, without evaluating its role in the invasion, angiogenesis or metastasis of gastric cancer, future study should focus on the effect of other components of the TME on the malignant progression in gastric cancer.