Of note, studies have shown a common functional variant in GCKR (rs1260326) associated with increased translocation of GK from GK-GKRP complex, lower fasting plasma glucose, but with increased de novo lipogenesis, non-alcoholic fatty liver disease (NAFLD) and higher serum triglycerides [40], as well as an increased risk of CAD [41]. This evidence concerns the gene GCKR and metabolic dysfunction-associated steatotic liver disease.