GK and coronary artery disorder: Though genetically predicted lower HbA1c also reduced risk of CAD (OR 0.76 per 1% lower HbA1c, 95% CI 0.58–0.98, P = 0.035), the risk-reducing effect size for CAD by genetically proxied GK activation was two-fold larger than that of genetically predicted lower HbA1c (Pdifference = 0.0006).