PIK3CA and osteosarcoma: Examples of the driver genes in tumorigenesis present in both species are: the homologous mutation to the human somatic BRAF p.V600E mutation in naturally occurring canine bladder cancer [9], the FBXW7 mutation in lymphomas [10], the recurrent somatic SETD2 mutation in osteosarcomas [11], the somatic TP53 and PIK3CA mutations in multiple cancers [12], the somatic mutations in TP53, PDGFRA, PIK3CA, EGFR and IDH1 in sporadic gliomas [13], and the NRAS, FAT4, PTEN and TP53 mutations in melanomas [14].