In addition, in a multivariate survival analysis including OX40 expression (high vs low expression), patients’ age (< 60 vs. ≥ 60 years), FLT3-ITD mutational status and ASCT status, OX40 expression on AML blasts was identified as independent risk factor for dismal outcome (Fig. 3f). This evidence concerns the gene TNFRSF4 and acute myeloid leukemia.